منابع مشابه
The Tail that Wags the Dog
Tails are of paramount importance in shaping the risk profile of portfolios with credit risk sensitive securities. In this context risk management tools require simulations that accurately capture the tails, and optimization models that limit tail effects. Ignoring the tails in the simulation or using inadequate optimization metrics can have significant effects and destroy portfolio efficiency....
متن کاملTail wags dog: primary cilia and tumorigenesis.
Aberrant activation of the Hedgehog (Hh) signaling pathway contributes to many forms of cancer. Primary cilia are Hh signal transduction centers. Two papers in a recent issue of Nature Medicine (Han et al., 2009; Wong et al., 2009) show that mutating cilia can increase or reduce the rates of tumorigenesis depending on how the Hh pathway is disrupted.
متن کاملThe tail that wags the dog: the globular tail domain defines the function of myosin V/XI.
Actin-based organelle movements are driven by the related multifunctional myosin motors of class V in animals and fungi and class XI in plants. The versatility of these motors depends critically on their C-terminal globular tail domain that allows them to bind to a broad variety of cargo molecules. Regulation of this motor-cargo attachment is frequently employed to modulate organelle movement. ...
متن کاملAbsence Epilepsy: The Tail WAGs the Rat.
Commentary If there is any " sure thing " in epilepsy, the syndrome of childhood absence epilepsy (CAE) may come close to fitting the bill. The characteristic seizure semiology (staring spells), response to specific medications (ethosuximide or valproate), and prognosis (often outgrown by late adolescence) are about as close as we get to a well-defined syndrome with reproducible clinical featur...
متن کاملBeware the tail that wags the dog: informal and formal models in biology
Informal models have always been used in biology to guide thinking and devise experiments. In recent years, formal mathematical models have also been widely introduced. It is sometimes suggested that formal models are inherently superior to informal ones and that biology should develop along the lines of physics or economics by replacing the latter with the former. Here I suggest to the contrar...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2008
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2008.02.012